�
According to a reputation published in the August 27 offspring of JAMA,
a drug that lowers uric acid levels, allopurinol, likewise seems to lower
rip pressure in adolescents with newly diagnosed hypertension (high
blood pressure).
Hyperuricemia - a condition characterized by higher than normal blood
levels of uric acid (a chemical institute in water and rip that results
from normal bodily processes) - is commonly associated with
hypertension. There has been some research to support uric acid's
causal role in hypertension, but hyperuricemia is not considered a true
risk divisor for high blood pressure as high uric acidulent in high blood pressure could be
due to several early factors. Experimental studies in laboratory
animals, however, have challenged this belief by indicating keep for
a causal purpose of uric acid in hypertension.
To influence the effect on high blood pressure of a uric acid-reducing drug,
Daniel I. Feig, M.D., Ph.D. (Baylor College of Medicine, Houston) and
colleagues conducted a randomized, placebo-controlled "crossover"
trial. The researchers studied hyperuricemic adolescents (11 to 17
years older) with freshly diagnosed high blood pressure to go out if the drug
allopurinol would reduce blood pressure sensation (BP). Feig and colleagues
randomly assigned thirty participants to receive either allopurinol or
placebo twice daily for quatern weeks. Following the initial
administration, thither was a two calendar week "washout" period during which the
patients did non receive anything, and then for four more weeks they
standard the therapy that they had non yet received.
The investigators base that allopurinol treatment was linked to a
significant decrease in casual and ambulatory systolic and diastolic
blood pressure. During zyloprim treatment, the average decrease in
casual BP was -6.9 mm Hg systolic and -5.1 mm Hg diastolic.
Participants taking placebo only presented changes of -2.0 and -2.4,
respectively. The researchers besides found that average changes in
24-hour ambulatory BP during allopurinol were -6.3 mm Hg, systolic and
-4.6, diastolic. There were slight increases in systolic BP during the
placebo phase (0.8 mm Hg) and slight decreases in diastolic BP (0.3 mm
Hg). In addition, the decrease in ambulant BP was directly correlate
with allopurinol treatment. Remarkably, during the allopurinol phase 20
of the 30 patients reached normal BP by casual and ambulatory criteria
compared to only 1 of 30 during the placebo phase.
"The results of this study present a potentially new therapeutic
approach, that of control of a biochemical cause of high blood pressure,
rather than nonspecifically lowering elevated BP. Although not
representing a fully developed therapeutic strategy, this sketch raises
an alternative strategy that english hawthorn prove to be more effective than
currently available options," drop a line Feig and colleagues.
They conclude: "Despite these findings, this clinical tribulation is a small
one and zyloprim is non indicated for the treatment of hypertension
in adolescents or other populations. The potential adverse effects of
allopurinol, including gastrointestinal complaints and especially
Stevens-Johnson syndrome [a severe, sensitised reaction], make
allopurinol an unattractive alternative to available antihypertensive
medications. More clinical trials ar needed to determine the
reproducibility of the data and whether it can buoy be generalised to the
larger hypertensive population. Nevertheless, the notice that
letting down uric acid can shrink BP in adolescents with newly diagnosed
hypertension raises intriguing questions about its role in the
pathogenesis of hypertension."
Effect of Allopurinol on Blood Pressure of Adolescents With
Newly Diagnosed Essential Hypertension: A Randomized Trial
Daniel I. Feig; Beth Soletsky; Richard J. Johnson
JAMA (2008). three hundred[8]:
pp. 924-932.
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Here to View Abstract
Written by: Peter M Crosta
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today
More information
Wednesday, 10 September 2008
Thursday, 21 August 2008
Glasvegas To Release Live In Glasgow DVD
Glasvegas have recorded a live DVD that will be apt away with limited edition copies of their debut album, as released on September 8th.
The bonus saucer features a gig as recorded in their native city of Glasgow at the ABC venue on June twentieth 2008. Five songs appear on the film - 'Flowers And Football Tops', 'It's My Own Cheating Heart That Makes Me Cry', 'Geraldine', 'Go Square Go' and 'Daddy's Gone'.
Also on the DVD are the promo videos for the singles 'Geraldine' and 'Daddy's Gone', as well as a documentary and an acoustic live version of 'Flowers And Football Tops'.
More info
Monday, 11 August 2008
Penile Prostheses For The Treatment Of Erectile Dysfunction
�UroToday.com - While cavernous dysfunction has been described since ancient times, enough treatment has only been available for the last three decades. Modern penial prosthetic devices were first developed in the early 1970s when Small et al. along with Scott et al. reported the implantation of penile prosthetic devices into the corpora cavernosa to fill the corpora cavernosa and provide a physiologically functional erection with good cosmetic results.
Semirigid retinal rod and mechanically skillful prostheses useable today are the successors of the devices intentional in the 1970s. These devices, while easier to implant, deliver few advantages over the newer inflatable devices because infection and mechanical malfunction rates ar similar. The semirigid devices consist of a central metal gist and a silicone elastomer rod while the mechanical Dura II implant is a serial publication of disks held in position by a fundamental cable. The latter intention facilitates positioning of the implant between uses.
The three-piece inflatable penile prostheses vary in construction from three-layer silicon/Dacron/Lycra to a single layer of atomic number 14 or Bioflex . Options include girth enlargement and/or length elongation. Design modifications over the past times two decades have decreased mechanical malfunction rates from greater than 30% to less than 5% and antibiotic coating has rock-bottom the infection rates from over 4% to fewer than 1%.
The three-piece inflatable penile prostheses continue to be the most satisfactory prostheses. These prosthetic devices produce the most natural appearing erecting in girth, length, and with satisfactory rigidity and excellent flabbiness for optimum concealment. They also have advantages for many patients with complex penile implantations because the flaccid position removes pressure from the corporal cavernosa and decreases the possibility of eating away in these highly difficult implantations.
Patients chosen for penile implantation therapy ar usually those that take failed PDE5 inhibitors and less encroaching therapy. Careful informed consent is critical in direction patients in front surgery. Post operatively patients should be counselled to cycle their devices day-by-day and that satisfaction increases over 3 to 6 months after implantation. Multicenter studies have documented the long term satisfaction and normal mechanical function of penile implants and their satisfaction rates. Patients queried 5 years after oR were exploitation their implants an median of terzetto times monthly.
Presented by: Culley C. Carson, MD, at the Masters in Urology Meeting - July 31, 2008 - August 2, 2008, Elbow Beach Resort, Bermuda
UroToday - the only urogenital medicine website with original message written by global urogenital medicine key view leaders actively engaged in clinical practice.
To access the latest urology news releases from UroToday, go to:
www.urotoday.com
Copyright � 2008 - UroToday
More info
Semirigid retinal rod and mechanically skillful prostheses useable today are the successors of the devices intentional in the 1970s. These devices, while easier to implant, deliver few advantages over the newer inflatable devices because infection and mechanical malfunction rates ar similar. The semirigid devices consist of a central metal gist and a silicone elastomer rod while the mechanical Dura II implant is a serial publication of disks held in position by a fundamental cable. The latter intention facilitates positioning of the implant between uses.
The three-piece inflatable penile prostheses vary in construction from three-layer silicon/Dacron/Lycra to a single layer of atomic number 14 or Bioflex . Options include girth enlargement and/or length elongation. Design modifications over the past times two decades have decreased mechanical malfunction rates from greater than 30% to less than 5% and antibiotic coating has rock-bottom the infection rates from over 4% to fewer than 1%.
The three-piece inflatable penile prostheses continue to be the most satisfactory prostheses. These prosthetic devices produce the most natural appearing erecting in girth, length, and with satisfactory rigidity and excellent flabbiness for optimum concealment. They also have advantages for many patients with complex penile implantations because the flaccid position removes pressure from the corporal cavernosa and decreases the possibility of eating away in these highly difficult implantations.
Patients chosen for penile implantation therapy ar usually those that take failed PDE5 inhibitors and less encroaching therapy. Careful informed consent is critical in direction patients in front surgery. Post operatively patients should be counselled to cycle their devices day-by-day and that satisfaction increases over 3 to 6 months after implantation. Multicenter studies have documented the long term satisfaction and normal mechanical function of penile implants and their satisfaction rates. Patients queried 5 years after oR were exploitation their implants an median of terzetto times monthly.
Presented by: Culley C. Carson, MD, at the Masters in Urology Meeting - July 31, 2008 - August 2, 2008, Elbow Beach Resort, Bermuda
UroToday - the only urogenital medicine website with original message written by global urogenital medicine key view leaders actively engaged in clinical practice.
To access the latest urology news releases from UroToday, go to:
www.urotoday.com
Copyright � 2008 - UroToday
More info
Wednesday, 6 August 2008
Precise Low-Dose Drug Monitoring Essential For Long-Term Kidney Transplant Success
�The ability of profligate
tests to precisely measuring very depleted doses of anti-rejection drugs in kidney
transplant patients may make a meaning difference in assuring long-term
viability and survival, according to research presented at the
American Association for Clinical Chemistry (AACC) annual meeting.
The current mentation in transpose medicine favors reducing doses of
tacrolimus and other immune-suppressive drugs as a great deal as possible after
kidney-transplant procedures. "Even though we are succeeding in preventing
organ rejection, we haven't made much progress to improve long-term
survival," said Sudarshan Hebbar, M.D., elderly medical conductor, Abbott
Diagnostics. "Unfortunately, most kidney transplant patients volition go back
on dialysis in eight to ten years, in part because the anti-rejection drugs
tin be toxic to the kidneys."
Dr. Hebbar added that kidney-transplant patients stimulate high incidence of
tests to precisely measuring very depleted doses of anti-rejection drugs in kidney
transplant patients may make a meaning difference in assuring long-term
viability and survival, according to research presented at the
American Association for Clinical Chemistry (AACC) annual meeting.
The current mentation in transpose medicine favors reducing doses of
tacrolimus and other immune-suppressive drugs as a great deal as possible after
kidney-transplant procedures. "Even though we are succeeding in preventing
organ rejection, we haven't made much progress to improve long-term
survival," said Sudarshan Hebbar, M.D., elderly medical conductor, Abbott
Diagnostics. "Unfortunately, most kidney transplant patients volition go back
on dialysis in eight to ten years, in part because the anti-rejection drugs
tin be toxic to the kidneys."
Dr. Hebbar added that kidney-transplant patients stimulate high incidence of
Thursday, 19 June 2008
Rudy Adrian
Artist: Rudy Adrian
Genre(s):
Ambient
Other
Electronic
Electronic: Progressive
Trance
New Age
Discography:
Concerts In The Usa
Year: 2003
Tracks: 7
Starfields
Year: 2002
Tracks: 5
Across An Ocean Of Dreams
Year: 2002
Tracks: 10
Iridescence Sequencer Sketches Vol. 2
Year: 2001
Tracks: 7
Concerts in New Zealand
Year: 2001
Tracks: 11
The Healing Lake
Year: 2000
Tracks: 9
Kinetic Flow
Year: 2000
Tracks: 7
Twilight: Atmospheric Works Vol.2
Year: 1999
Tracks: 10
Twilight
Year: 1999
Tracks: 10
Bob Baldwin
Thursday, 12 June 2008
The Infinity Project
Artist: The Infinity Project
Genre(s):
Trance: Psychedelic
Discography:
Alien Airport
Year: 1999
Tracks: 2
the Paper Chase
Friday, 6 June 2008
Ledger's death is ruled accidental
The death of Australian actor Heath Ledger has been ruled accidental by the New York City Medical Examiner's Office.
The office said today that the 28-year-old actor died due to the abuse of prescription medications.
A statement said: "Mr Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine."
"We have concluded that the manner of death is accident, resulting from the abuse of prescription medications."
The actor's family released a statement saying: "Today's results put an end to speculation, but our son's beautiful spirit and enduring memory will forever remain in our hearts."
"While no medications were taken in excess, we learned today the combination of doctor-prescribed drugs proved lethal for our boy."
The statement also said: "Heath's accidental death serves as a caution to the hidden dangers of combining prescription medication, even at low dosage."
Ledger was found dead at his New York apartment on 22 January.
The office said today that the 28-year-old actor died due to the abuse of prescription medications.
A statement said: "Mr Heath Ledger died as the result of acute intoxication by the combined effects of oxycodone, hydrocodone, diazepam, temazepam, alprazolam, and doxylamine."
"We have concluded that the manner of death is accident, resulting from the abuse of prescription medications."
The actor's family released a statement saying: "Today's results put an end to speculation, but our son's beautiful spirit and enduring memory will forever remain in our hearts."
"While no medications were taken in excess, we learned today the combination of doctor-prescribed drugs proved lethal for our boy."
The statement also said: "Heath's accidental death serves as a caution to the hidden dangers of combining prescription medication, even at low dosage."
Ledger was found dead at his New York apartment on 22 January.
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